CRISPR Cas9

What is CRISPR Cas9

CRISPR Cas9 system is recently considered as the most remarkable breakthrough in genome editing technology. Compared with the existing TALEN and ZFN, CRISPR Cas9 system can provide more precise DNA modification through the RNA-directed Cas9 nucleases. Previous studies have indicated that the on-target gene knockout rate is higher than that of TALEN and ZFN, and the CRISPR Cas9 system is more efficient and economical. CRISPR/Cas9, the most promising gene editing tool, has been widely applied to animal and plant breeding, directed evolution, and the site-specific restoration of genetic diseases.

CRISPR Cas9 applications:

CRISPR-Platform

CRISPR Cas9 Services

CRISPR-Cas9-sgRNA-Design-Center CRISPR Cas9 sgRNA Design Center

CRISPR-Cas9-sgRNA-Library-Design-and-Screening CRISPR Cas9 sgRNA Library Design and Screening

CRISPR-Cas9-sgRNA-Panel CRISPR Cas9 sgRNA Panel

Mammalian-Cell-Line-Gene-Editing Mammalian Cell Line Gene Editing

Yeast-Genome-Editing Yeast Genome Editing

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References
1.Shalem O, Sanjana N E, Hartenian E, et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science, 2014, 343(6166): 84-87.
2.Cong L, Ran F A, Cox D, et al. Multiplex genome engineering using CRISPR/Cas systems. Science, 2013, 339(6121): 819-823.
2.Hsu P D, Lander E S, Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell, 2014, 157(6): 1262-1278.
3.Yang L, Güell M, Niu D, et al. Genome-wide inactivation of porcine endogenous retroviruses (PERVs). Science, 2015, 350(6264): 1101-1104.
4.Liang P, Xu Y, Zhang X, et al. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein & cell, 2015, 6: 363-372.