CRISPR Cas9 system is recently considered as the most remarkable breakthrough in genome editing technology. Compared with the existing TALEN and ZFN, CRISPR Cas9 system can provide more precise DNA modification through the RNA-directed Cas9 nucleases. Previous studies have indicated that the on-target gene knockout rate is higher than that of TALEN and ZFN, and the CRISPR Cas9 system is more efficient and economical. CRISPR/Cas9, the most promising gene editing tool, has been widely applied to animal and plant breeding, directed evolution, and the site-specific restoration of genetic diseases.
CRISPR Cas9 applications:
|CRISPR Cas9 sgRNA Design Center||CRISPR Cas9 sgRNA Library Design and Screening|
|CRISPR Cas9 sgRNA Panel||Mammalian Cell Line Gene Editing|
|Yeast Genome Editing|
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4.Liang P, Xu Y, Zhang X, et al. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein & cell, 2015, 6: 363-372.