Biological drugs usually include genetic engineering drugs, antibody engineering drugs, blood products drugs, and vaccines etc. Among these, antibody drugs are one of the fastest growing human therapeutic drugs. Synbio Technologies’ Antibody Platform utilizes molecular simulation technologies to provide antibody de novo design and preparation services. We use this platform to simulate various biological behaviors of antibody molecules on the atomic level. We can analyze the antibody structure as a starting point to solve a series of problems such as the theoretical design of an antibody. The combination of the molecular simulation technology and experimental approach can help our customers effectively reduce the total cost of antibody R&D to effectively shorten the R&D cycle.
Featured Advantages
- Cloud computing
- Supercomputing
- Antibodies humanization
- Affinity maturation
- Full human antibody library design
- High-throughput antibody modeling
- Effective antigen-antibody docking
Service Specifications
Service | Details | Turnaround Time | Deliverables | Price |
---|---|---|---|---|
Syno® Ab Antibody Design and Production |
| 2-3 Weeks |
| Inquire |
* Customers can provide the antigen name or gene ID directly; If you have antigen crystal structure, please contact us directly.
Service flow

Case Study
- Extracted the H1, H2, H3, L1, L2 and L3 regions of the antibody from the PDB database
- Created CDRs library
- Created germline
- Assembled the CDR into the germline template
- Created a complete antibody structure
- Docked antigens with the antibody library
- Sorted optimized antibodies based on interaction energy
- Selected the best antibody based on evaluation
- Antibody affinity modification
- Synthesized the first 100 antibody sequences
- Searched template
- Constructed an antibody backbone
- Constructed the side chain of target protein
- Constructed loop region
- Final optimization of structure

5. Results

Figure 1. Anti-antibody complex structure predicted by Synbio Technologies (the epitope is similar to the crystal structure of Figure 2)

Figure 2. Crystal structure of the antigen-antibody complex from the PDB database
6. Final data
Designed 1~100 antibody sequences for antigen, all affinities were greater than 10-10M.
Statistical table of affinity test results
Loading Sample ID | kon(1/Ms) | kdis(1/s) | KD (M) |
---|---|---|---|
55_56 | 9.28E+03 | 2.70E-07 | 2.91E-11 |
57_58 | 3.76E+03 | 5.60E-07 | 1.49E-10 |
75_76 | 7.29E+04 | 8.90E-07 | 1.22E-11 |