Category: Synthetic Biology

The Application of Synthetic Biology to Human Health and Medicine

Synthetic biology is a new interdisciplinary subject established in bioinformatics, DNA synthetic technology, genetics, and systems biology. Synthetic biology is the rational and systematic design/construction of biological systems with desired functionality. One of its most powerful tools is DNA synthesis technology; recently, the cost of gene synthesis has dropped 10 fold over the past 15 years, leading to a boom in the development of synthetic biology. As we understand more about gene synthesis and its applications, the benefits of synthetic biology could reach a wide variety of different fields, including medicine, agriculture, drug development, and bioengineering.

The application of synthetic biology to human health

Synthetic biology technology has potential uses in clinical treatments that can synthesize gene circuits to screen for pathogenic gene or structure variants in diseased animal models. Currently, scientists have synthesized a number of gene circuits in mammalian cells, potentially leading to the treatment and outright prevention of many genetic diseases in humans. Synthetic biology can also lead to treatment for metabolic disorders. For example, Dean et al. incorporated a synthetic gene circuit encoding the glyco-oxylate shunt pathway into mice liver cells, resulting in increased fatty acid oxidation.

The application of synthetic biology to medicine

Synthetic biology is useful to drug screening and discovery, and can be used to discover new drug targeting sites. With the rapid development of synthetic biology, new tools in bioinformatics can be used to analyze potential drug targets. Computational biology and new technology can rapidly identify true protein coding sequences from DNA sequence data, providing accurate predictions of coding vs noncoding sequences.

Synbio Technologies is a DNA technology company that specializes in synthetic biology research. We can artificially design and engineer biological systems and living organisms for the purposes of improving applications for industry or biological research. Synbio Technologies has its own professional synthetic biology platform to provide integrated solutions for all of our customers’ synthetic biology research.

Synthetic Biology and Drug Discovery

Synthetic biology utilizes information from fields such as biotechnology, molecular biology, molecular engineering, and many more in order to design and build novel biological functions and systems. Synthetic biology is the engineering of biology itself, and will have profound implications on all levels of biological structure.

One of the applications of synthetic biology is to design or discover new drugs that can be used for agriculture or medicine. Today we know the molecular cause of almost 4,000 different diseases, but have available treatments for only 250 of them. With synthetic biology, new drugs that are capable of addressing the root cause of these diseases could be found more quickly and efficiently.

Drug discovery involves screening small molecules for their ability to modulate biological pathways in cells or organisms, with no regard for any particular protein target. This process is likely to benefit in the future from an evolving forward analysis of synthetic biology, that leads to structurally complex and diverse small molecules. Tools in synthetic biology enable disease mechanisms and target identification to be elucidated, providing avenues to discover small chemotherapeutic molecules. Engineering the genes into the host organism sucessfully will involve recoding the DNA entirely, screening the right codons to ensure that the sequence is expressed correctly. In addition, synthetic biology can provide techniques that help to design generic and affordable drugs, which could help overcome global drug shortages.

More attention and resources dedicated to synthetic biology could lead to better development of the design, construction, and optimization of biochemical pathways, and the development of high-throughput genome engineering tools for mammalian synthetic biology applications. The opportunities and challenges presented by synthetic biology are exciting and hold a wealth of untapped potential, and could lead us into a revolutionary new take on medicine.

How Synthetic Biology Leads to Renewable Energy

Synthetic Biology aims to engineer the nature organisms that the system can perform new fuction or construct new material. Biofuel refers to solid, liquid, or gaseous fuel produced through contemporary biological processes, such as agriculture and anaerobic digestion. Biofuel has great potential to replace petroleum, gasoline, and diesel, and is an important factor in the development and utilization of renewable energy. Whether derived directly from plants, or indirectly from agricultural, commercial, domestic, and/or industrial waste, biofuels are a major source of green, renewable energy that will only become more useful and more affordable as time goes on.

Microbial fermentation is one of the most effective ways to produce biological energy. Glucose is a highly cost-effective raw material often used in this production process. The process of designing, constructing, and optimizing microbial synthesis is defined as metabolic engineering. More and more gene regulations need to be considered while designing the metabolic pathway, especially as metabolic engineering continues to evolve and expand to broader and more advanced fields – such as synthetic biology. Synthetic biology deals with the systematic design and the formation of new biological components, such as enzymes, genetic circuits, metabolic pathways, and cells.

Synthetic biology has developed rapidly over the past ten years. A large number of highly efficient and practical synthetic biology tools have been developed and applied to biofuel development. Through the design, control, and optimization of microbial synthesis processes at the enzymatic, metabolic pathway, and genomic levels, new biofuels and the optimization of yield of already available biofuels could be right around the corner.

Synbio Technologies has created the first integrated GPS (Genotype, Phenotype, and Synotype) system designed for quick and easy translation or reverse translation between Genotype and Phenotype by using our proprietary Synotype platform. We have created comprehensive Synotype platforms for biological researchers that are dedicated to integrating cutting-edge synthetic biology techniques and bioinformatics tools into an advanced biological innovation platform. Synbio Technologies’s scientific capabilities encompass areas such as DNA engineering, DNA synthesis, genome synthesis, pathway synthesis, synthetic biology, pharmacogenomics, microbiology, translational biology and the applications of synthetic biology.

Synthetic Biology Services

Synbio Technologies is devoted to synthetic biology and the development of related products. Synthetic biology facilitates tasks like editing an existing gene/genome or redesigning a novel metabolism pathway, to suit any and all consumer needs. Our synthetic biology services cover a broad range of DNA technologies, including reading, writing, and editing of DNA. Synthetic biology can simply synthesis DNA sequence without DNA template with fast turnaround. Our proprietary Syno® platforms can quickly provide professional and custom synthetic biology services in biology, medicine, agriculture, bio-fuel and environment industries. Our experienced team of engineers are also available for on-demand customer assistance via email or phone, and will help you with any problems or concerns you may have.

Synthetic Biology Services include:

  • de novo DNA synthesis

    e.g. Syno® 2.0 gene synthesis , Syno® 3.0 next generation DNA synthesis. Our Syno® platforms guarantee high-throughput, low price, and 100% accurate gene synthesis services.

  • Library design provide efficient gene screening services
  • DNA editing

    e.g. CRISPR-Cas9 gene editing platform and CRISPR-Cas9 sgRNA synthesis services.

  • DNA sequencing and gene analysis
  • Molecular biology services

    e.g. plasmid DNA preparation, PCR cloning & subcloning, and site-directed mutagenesis

  • Recombinant protein expression and purification
  • Antibody discovery

For more details on the synthetic biology services we provide, please contact us through our customer information system, through email, or by calling us. More information on our synthetic biology services can be found on our website.

Synthetic Biology Definition

Synthetic biology refers to the design and construction of novel biological components, systems, and technologies through logic and existing biological knowledge. Synthetic biology is a relatively new discipline, emerging during the 20th century. Since then, many breakthroughs have been achieved in research on the synthesis of biological materials, especially in recent years. Compared to traditional biology, which focuses on the internal, structural, and functional investigation of organisms via dissection or other traditional biology, synthetic biology instead focuses on constructing biological technologies from basic elements. Synthetic biology also differs from genetic engineering, which focuses on extension and modification of an organism’s genetic material and its transfer to another organism. Some main concepts in synthetic biology are as follows:

  1. Synthetic biology touches upon synthesis and modularization of various molecules as well as sub-cellular module construction by utilizing biological synthesis genetic networks and metabolism and signaling pathways.
  2. Develop platforms that optimize biological and non-biological carriers to raise the efficiency of engineering systems, reduce maintenance level and cost, and provide robustness and environmental compatibility.
  3. Regulate communication systems including feedback and feed-forward mechanisms of biological gadgets, as well as modularization of their behavior and means of communication.
  4. Conduct simulations and algorithm forecasts, and build relevant software systems for various functional modules. In particular, computer-aided technology is an effective tool to reduce experimental costs and complexity.

Synthetic biology which is a relatively new technology, starts from the basic elements of building components step by step form external instead of studying its internal structure. Synbio Technologies has developed propriety Syno® 3.0 DNA synthesis platform which can significantly improve the throughput and reduce the cost of gene synthesis. You can count on Syno® platforms that are the highest quality standard in the market regarding to gene synthesis, genome synthesis, pathway synthesis and comprehensive synthetic biology applications.

Synthetic Biology Application

Synthetic biology is a promising new discipline with many potential applications for cell biology, microbiology, biochemistry, and many other related fields. There are four main aspects of synthetic biology: studying cellular networks, redesigning genetic pathways for gene-to-protein expression, acquiring novel green material and fueling substance, and providing a simple environment without interference for inserting function modules.

Synthetic biology has a great deal of potential in designing more effective vaccines and drugs, enhancing drug efficacy, utilizing renewable energy sources to produce sustainable energy, curbing environmental pollution via biological means, and building sensors that are able to detect poisonous chemical substances. Synthetic biology has a lot of potential to revolutionize information storage by using synthetic DNA to encode large quantities of data.

In addition to its role in medicine, synthetic biology also helps the development of biological fuel and agriculture technology. Synthetic biology combines biology with engineering concepts, redesigning existing biological systems and adding new biological modules and machines to it, creating artificial life systems not found in nature.

As various technologies for synthetic biology continue to mature and develop, the applications of synthetic biology will expand to even broader fields, playing a crucial role in solving various problems related to energy, environment, medicine, and drug design for mankind.