Customer Academic Publications

Gene Synthesis

Chang, Z., Meng, F., Zhang, Z., Mao, G., Huang, Z., Liao, W., & He, A. (2018). MicroRNA-193b-3p regulates matrix metalloproteinase 19 expression in interleukin-1β-induced human chondrocytes. Journal of Cellular Biochemistry,119(6), 4775-4782. doi:10.1002/jcb.26669

Cheng, Y., Chen, G., Wang, L., Kong, J., Pan, J., Xi, Y., . . . Huang, Z. (2018). Triptolide-induced mitochondrial damage dysregulates fatty acid metabolism in mouse sertoli cells. Toxicology Letters,292, 136-150. doi:10.1016/j.toxlet.2018.04.035

Dai, S., Zhang, J., Huang, S., Lou, B., Fang, B., Ye, T., . . . Zhou, M. (2017). HNRNPA2B1 regulates the epithelial–mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway. Cancer Cell International,17(1). doi:10.1186/s12935-016-0368-4

Duan, L., Ding, W., Liu, X., Cheng, X., Cai, J., Hua, E., & Jiang, H. (2017). Biosynthesis and engineering of kaempferol in Saccharomyces cerevisiae. Microbial Cell Factories,16(1). doi:10.1186/s12934-017-0774-x

Gong, S., & Wu, C. (2019, February 1). Generation of Fabs-in-tandem immunoglobulin molecules for dual-specific targeting. Methods,154, 87-92. doi:10.1016/j.ymeth.2018.07.014

He, P., Li, Y., Luo, J., Wang, H., Yan, Y., & Chen, Z. (2017). Development and Application of A Duplex Real-Time RT-PCR Assay for Simultaneous Detection of Coxsackievirus A6 and Coxsackievirus A10. Ann Clin Lab Sci,47(March), 2nd ser., 178-183. PMID: 28442520

Hu, X., Xu, X., He, B., Sun, H., Xu, T., Liu, X., . . . Pan, Y. (2018). MicroRNA-485-5p Functions as a Tumor Suppressor in Colorectal Cancer Cells by Targeting CD147. Journal of Cancer,9(15), 2603-2611. doi:10.7150/jca.24918

Jin, L., Miao, J., Liu, Y., Li, X., Jie, Y., Niu, Q., & Han, X. (2017). Icaritin induces mitochondrial apoptosis by up-regulating miR-124 in human oral squamous cell carcinoma cells. Biomedicine & Pharmacotherapy,85, 287-295. doi:10.1016/j.biopha.2016.11.023

Jin, W., Li, S., Chen, J., Liu, B., Li, J., Li, X., . . . Zhong, W. (2018). Increased soluble heterologous expression of a rat brain 3- O -sulfotransferase 1 – A key enzyme for heparin biosynthesis. Protein Expression and Purification,151, 23-29. doi:10.1016/j.pep.2018.06.007

Li, J., Zhang, Y., Zhang, Y., Lü, S., Miao, Y., Yang, J., . . . Feng, J. (2018). GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation. Redox Biology,17, 386-399. doi:10.1016/j.redox.2018.04.021

Li, N., Yi, L., He, Z., Zhang, W., Li, H., & Lin, J. (2017). A DNA-directed covalent conjugation fluorescence probe for in vitro detection of functional matrix metalloproteinases. The Analyst,142(4), 634-640. doi:10.1039/c6an02339h

Li, Z., Feng, S., Zhou, L., Liu, S., & Cheng, J. (2016). NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1. Biochemical and Biophysical Research Communications,475(1), 133-139. doi:10.1016/j.bbrc.2016.05.056

Lu, H., Bai, Y., Fan, T., Zhao, Y., Zheng, X., & Cai, Y. (2018). Identification of a l -Lactate dehydrogenase with 3,4-dihydroxyphenylpyruvic reduction activity for l -Danshensu production. Process Biochemistry,72, 119-123. doi:10.1016/j.procbio.2018.06.011

Liu, J., Chen, W., Zhang, H., Liu, T., & Zhao, L. (2017). MiR‑214 targets the PTEN‑mediated PI3K/Akt signaling pathway and regulates cell proliferation and apoptosis in ovarian cancer. Oncology Letters. doi:10.3892/ol.2017.6953

Na, R., Jiajia, L., Dongliang, Y., Yingzi, P., Juan, H., Xiong, L., . . . Yitian, L. (2016). Indentification of vincamine indole alkaloids producing endophytic fungi isolated from Nerium indicum , Apocynaceae. Microbiological Research,192, 114-121. doi:10.1016/j.micres.2016.06.008

Pan, X., Wang, H., Tong, D., Wang, C., Sun, L., Zhao, C., . . . Wu, D. (2016). Physcion induces apoptosis in hepatocellular carcinoma by modulating miR-370. Am J Cancer Res,6(Dec), 12th ser., 2919-2931. PMID: 28042511

Pan, Y., Sun, H., Hu, X., He, B., Liu, X., Xu, T., . . . Wang, S. (2018). The inhibitory role of miR‑485‑5p in colorectal cancer proliferation and invasion via targeting of CD147. Oncology Reports. doi:10.3892/or.2018.6309

Peng, C., Liu, Y., Guo, X., Liu, W., Li, Q., & Zhao, Z. K. (2018, October 17). Selective carboxylation of substituted phenols with engineered Escherichia coli whole-cells. Tetrahedron Letters,59(42), 3810-3815. doi:10.1016/j.tetlet.2018.09.019

Shi, J., Wang, X., Zhu, H., Jiang, H., Wang, D., Nesvizhskii, A., & Zhu, H. (2018, August 24). Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method. Journal of Proteome Research,17(10), 3606-3612. doi:10.1021/acs.jproteome.8b00620

Shi, J., Wang, X., Zhu, H., Jiang, H., Wang, D., Nesvizhskii, A., & Zhu, H. (2018). Determining Allele-Specific Protein Expression (ASPE) Using a QconCAT-Based Proteomics Method: A Novel Approach to Identify Cis-acting Genetic Variants. doi:10.1101/264614

Si, X., Zhang, X., Hao, X., Li, Y., Chen, Z., Ding, Y., . . . Zhou, Y. (2016). Upregulation of miR-99a is associated with poor prognosis of acute myeloid leukemia and promotes myeloid leukemia cell expansion. Oncotarget,7(47). doi:10.18632/oncotarget.12947

Su, J., Gao, J., Si, Y., Cui, L., Song, C., Wang, Y., . . . Zhou, Y. (2017, March). Galectin-10: A new structural type of prototype galectin dimer and effects on saccharide ligand binding. Glycobiology,28(3), 159-168. doi:10.1093/glycob/cwx107

Tang, Y., Cui, Y., Li, Z., Jiao, Z., Zhang, Y., He, Y., . . . Zhang, S. (2016). Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells. Journal of Experimental & Clinical Cancer Research,35(1). doi:10.1186/s13046-016-0285-3

Wang, J., Chen, S., Xiao, W., Li, W., Wang, L., Yang, S., . . . Zhou, P. (2018, January 10). CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia. Journal of Hematology & Oncology,11(1). doi:10.1186/s13045-017-0553-5

Wang, L., Liang, C., Wu, J., Liu, L., & Tyo, K. E. (2017). Increased Processivity, Misincorporation, and Nucleotide Incorporation Efficiency in Sulfolobus solfataricus Dpo4 Thumb Domain Mutants. Applied and Environmental Microbiology,83(18). doi:10.1128/aem.01013-17

Wang, X., Zhou, Y. J., Wang, L., Liu, W., Liu, Y., Peng, C., & Zhao, Z. K. (2017). Engineering Escherichia coli Nicotinic Acid Mononucleotide Adenylyltransferase for Fully Active Amidated NAD Biosynthesis. Applied and Environmental Microbiology,83(13). doi:10.1128/aem.00692-17

Wang, X., Wang, L., Lin, X., Yang, X., Liu, W., & Zhao, Z. K. (2017). Visualizing Soluble Protein Mutants by Using Monomeric Red Fluorescent Protein as a Reporter for Directed Evolution. Applied Biochemistry and Biotechnology,185(1), 81-90. doi:10.1007/s12010-017-2640-z

Xie, Z., Liu, D., Li, B., Zhao, M., Zeng, B., Wu, Y., . . . Yuan, Y. (2017). Design and chemical synthesis of eukaryotic chromosomes. Chemical Society Reviews,46(23), 7191-7207. doi:10.1039/c7cs00208d

Yang, H., Zhu, Q., Zhou, N., & Tian, Y. (2016). Optimized expression of prolyl aminopeptidase in Pichia pastoris and its characteristics after glycosylation. World Journal of Microbiology and Biotechnology,32(11). doi:10.1007/s11274-016-2135-z

Yang, X., Sun, W., Shen, H., Zhang, S., Jiao, X., & Zhao, Z. K. (2018). Expression of phosphotransacetylase in Rhodosporidium toruloides leading to improved cell growth and lipid production. RSC Advances,8(43), 24673-24678. doi:10.1039/c8ra03028f

Zhang, W., He, Z., Yi, L., Mao, S., Li, H., & Lin, J. (2018). A dual-functional microfluidic chip for on-line detection of interleukin-8 based on rolling circle amplification. Biosensors and Bioelectronics,102, 652-660. doi:10.1016/j.bios.2017.12.017

Zhao, Z., Xue, J., Song, Y., Liu, T., & Piao, D. (2017). Downregulated long non‑coding RNA TCONS_00068220 upregulates apoptosis in gastric cancer cells. Oncology Letters. doi:10.3892/ol.2017.6977

Zhi, N., Wan, Z., Liu, X., Wong, S., Kim, D. J., Young, N. S., & Kajigaya, S. (2010). Codon Optimization of Human Parvovirus B19 Capsid Genes Greatly Increases Their Expression in Nonpermissive Cells. Journal of Virology,84(24), 13059-13062. doi:10.1128/jvi.00912-10

Gene Cloning

Hu, J., Tian, J., Li, F., Xue, B., Hu, J., Cheng, X., . . . Li, B. (2017). Clone and functional analysis of Seryl-tRNA synthetase and Tyrosyl-tRNA synthetase from silkworm, Bombyx mori. Scientific Reports,7(1). doi:10.1038/srep41563

Yan, H., Zhang, Y., Zhang, Y., Ren, X., Shen, Y., Cheng, M., & Zhang, Y. (2017). CRIF1 enhances p53 activity via the chromatin remodeler SNF5 in the HCT116 colon cancer cell lines. Biochimica Et Biophysica Acta (BBA) – Gene Regulatory Mechanisms,1860(4), 516-522. doi:10.1016/j.bbagrm.2017.02.006

sgRNA Library

Lu, Y., Ye, X., Guo, R., Huang, J., Wang, W., Tang, J., . . . Qian, Y. (2017). Genome-wide Targeted Mutagenesis in Rice Using the CRISPR/Cas9 System. Molecular Plant,10(9), 1242-1245. doi:10.1016/j.molp.2017.06.007

Codon Optimization

Liu, B., Kong, Q., Zhang, D., & Yan, L. (2018). Codon optimization significantly enhanced the expression of human 37-kDa iLRP in Escherichia coli. 3 Biotech,8(4). doi:10.1007/s13205-018-1234-y

Jin, W., Li, S., Chen, J., Liu, B., Li, J., Li, X., . . . Zhong, W. (2018). Increased soluble heterologous expression of a rat brain 3- O -sulfotransferase 1 – A key enzyme for heparin biosynthesis. Protein Expression and Purification,151, 23-29. doi:10.1016/j.pep.2018.06.007

Zhang, P., Wang, Z., Sheng, J., Zheng, Y., Ji, X., Zhou, H., . . . Chi, Z. (2018). High and efficient isomaltulose production using an engineered Yarrowia lipolytica strain. Bioresource Technology,265, 577-580. doi:10.1016/j.biortech.2018.06.081

Oligo Synthesis

Chen, S., Yang, J., Zhang, Y., Duan, C., Liu, Q., Huang, Z., . . . Xu, G. (2018). Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1. Journal of Biological Chemistry,293(29), 11296-11309. doi:10.1074/jbc.ra117.001432

Fang, B., Chen, X., Wu, M., Kong, H., Chu, G., Zhou, Z., . . . Chen, B. (2018). Luteolin inhibits angiogenesis of the M2‑like TAMs via the downregulation of hypoxia inducible factor‑1α and the STAT3 signalling pathway under hypoxia. Molecular Medicine Reports. doi:10.3892/mmr.2018.9250

Nie, H., Nie, D., & Men, L. (2018). Role of miR-214 in modulating proliferation and invasion of human colon cancer SW620 cells. Oncology Letters. doi:10.3892/ol.2018.9521

Sun, Y., Zou, H., Yang, L., Zhou, M., Shi, X., Yang, Y., . . . Lu, Y. (2018). Effect on the liver cancer cell invasion ability by studying the associations between autophagy and TRAP1 expression. Oncology Letters. doi:10.3892/ol.2018.8774

Wang, J., Wang, F., Zhu, J., Song, M., An, J., & Li, W. (2018). Transcriptome Profiling Reveals PHLDA1 as a Novel Molecular Marker for Ischemic Cardiomyopathy. Journal of Molecular Neuroscience,65(1), 102-109. doi:10.1007/s12031-018-1066-6

Wang, J., Zhu, M., Wang, L., Chen, C., & Song, Y. (2019). Amphiregulin potentiates airway inflammation and mucus hypersecretion induced by urban particulate matter via the EGFR-PI3Kα-AKT/ERK pathway. Cellular Signalling,53, 122-131. doi:10.1016/j.cellsig.2018.10.002

Wang, J., Huang, J., Wang, L., Chen, C., Yang, D., Jin, M., . . . Song, Y. (2017). Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway. Journal of Thoracic Disease,9(11), 4398-4412. doi:10.21037/jtd.2017.09.135

Wang, Q., Wang, Y., Xing, Y., Yan, Y., Guo, P., Zhuang, J., . . . Zhang, J. (2016). Physcion 8- O -β-glucopyranoside induces apoptosis, suppresses invasion and inhibits epithelial to mesenchymal transition of hepatocellular carcinoma HepG2 cells. Biomedicine & Pharmacotherapy,83, 372-380. doi:10.1016/j.biopha.2016.06.045

Yu, D., Ye, T., Xiang, Y., Shi, Z., Zhang, J., Lou, B., . . . Zhou, M. (2017). Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial–mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells. OncoTargets and Therapy,Volume 10, 4719-4729. doi:10.2147/ott.s136840

Zhang, H., Zhang, Z., Jia, L., Ji, W., & Li, H. (2018). Genetic Polymorphism in the RYR1 C6487T Is Associated with Severity of Hypospadias in Chinese Han Children. BioMed Research International,2018, 1-7. doi:10.1155/2018/7397839

Zhang, Y., Pan, C., Wang, J., Cao, J., Liu, Y., Wang, Y., & Zhang, L. (2017). Genetic and immune features of resectable malignant brainstem gliomas. Oncotarget,8(47). doi:10.18632/oncotarget.19653

Zhang, Z., Liu, Y., Liu, P., Yang, L., Jiang, X., Luo, D., & Yang, D. (2017). Non-invasive detection of gastric cancer relevant d-amino acids with luminescent DNA/silver nanoclusters. Nanoscale,9(48), 19367-19373. doi:10.1039/c7nr07337b

Probe Synthesis

Eastwood, M. P., Deprest, J., Russo, F. M., Wang, H., Mulhall, D., Iwasiow, B., . . . Keijzer, R. (2018). MicroRNA 200b is upregulated in the lungs of fetal rabbits with surgically induced diaphragmatic hernia. Prenatal Diagnosis,38(9), 645-653. doi:10.1002/pd.5318

Wu, Y., Li, X., Tan, X., Feng, D., Yan, J., Zhang, H., . . . Han, H. (2018). A cyclic catalysis enhanced electrochemiluminescence aptasensor based 3D graphene/photocatalysts Cu 2 O-MWCNTs. Electrochimica Acta,282, 672-679. doi:10.1016/j.electacta.2018.06.104

Zhang, Y., Pan, C., Wang, J., Cao, J., Liu, Y., Wang, Y., & Zhang, L. (2017). Genetic and immune features of resectable malignant brainstem gliomas. Oncotarget,8(47). doi:10.18632/oncotarget.19653


Chen, M., Zhai, J., Liu, Y., Xue, B., Hu, J., Cheng, X., . . . Li, B. (2018). Molecular cloning and characterization of C 1 tetrahydrofolate (C 1 -THF) synthase in Bombyx mori , silkworm. Gene,663, 25-33. doi:10.1016/j.gene.2018.04.037

Cheng, H., Luo, Z., Lu, M., Gao, S., & Wang, S. (2017). The hyperthermophilic α-amylase from Thermococcus sp. HJ21 does not require exogenous calcium for thermostability because of high-binding affinity to calcium. Journal of Microbiology,55(5), 379-387. doi:10.1007/s12275-017-6416-5

Tang, X., Li, P., Zhang, Q., Zhang, Z., Zhang, W., & Jiang, J. (2017). Time-Resolved Fluorescence Immunochromatographic Assay Developed Using Two Idiotypic Nanobodies for Rapid, Quantitative, and Simultaneous Detection of Aflatoxin and Zearalenone in Maize and Its Products. Analytical Chemistry,89(21), 11520-11528. doi:10.1021/acs.analchem.7b02794

Yang, F., Guo, L., Lyu, K., Zhang, J., Yang, Y., Wang, H., . . . Huo, Y. (2018). Local Polyploidy Phenomenon inEscherichia coliand its significance in genetic engineering. doi:10.1101/335448

Vector Construction

Bellido, F., Sowada, N., Mur, P., Lázaro, C., Pons, T., Valdés-Mas, R., . . . Valle, L. (2018). Association Between Germline Mutations in BRF1 , a Subunit of the RNA Polymerase III Transcription Complex, and Hereditary Colorectal Cancer. Gastroenterology,154(1). doi:10.1053/j.gastro.2017.09.005

Chu, J., Li, Y., Fan, X., Ma, J., Li, J., Lu, G., . . . Yuan, H. (2018). MiR-4319 Suppress the Malignancy of Triple-Negative Breast Cancer by Regulating Self-Renewal and Tumorigenesis of Stem Cells. Cellular Physiology and Biochemistry,48(2), 593-604. doi:10.1159/000491888

Xu, X., Song, C., Chen, Z., Yu, C., Wang, Y., Tang, Y., & Luo, J. (2018). Downregulation of HuR Inhibits the Progression of Esophageal Cancer through Interleukin-18. Cancer Research and Treatment,50(1), 71-87. doi:10.4143/crt.2017.013

DNA Storage

Zhong, Y., Qi, S., Sheng, F., Tian, J., Zhu, P., Yang, P., & Cai, X. (2017). A new digital information storing and reading system based on synthetic DNA. Science China Life Sciences,61(6), 733-735. doi:10.1007/s11427-017-9131-7

RNA Interference

Ren, Y., Chen, J., Wu, X., Gui, C., Mao, K., Zou, F., & Li, W. (2018). Role of c-Abl-GSK3β Signaling in MPP -Induced Autophagy-Lysosomal Dysfunction. Toxicological Sciences,165(1), 232-243. doi:10.1093/toxsci/kfy155