In the world of synthetic biology, artificial gene synthesis is quickly becoming a crucial technique. The ability to customize and create DNA sequences has opened up an array of possibilities for synthetic DNA. Scientists can now create new DNA sequences from scratch, or even induce mutations in existing sequences, making it substantially easier to study mutant phenotypes.
One significant limitation has always been the length of the genes that can be synthesized. Oligonucleotide synthesis technology typically yields chemically synthetic gene constructs of around 200 nucleotides, while Gibson assembly is limited to plasmids of around 10kb or less. However, advances in technology have opened up new possibilities.
Scientists have been working with yeast as a system of choice for its ability to self-connect multiple DNA fragments rapidly, without the need for polymerase or ligase. This, combined with the proprietary Syno platform, has revolutionized gene synthesis. With built-in homologous recombination technology, yeast can assemble various long DNA fragments, and even construct genomes up to 150kb.
Today, Synbio Technologies delivers over 2 million base pairs of DNA sequences worldwide every month. They offer low-cost methods to accomplish gene synthesis and assemble long DNA segments with high accuracy and yield. Synbio Technologies can synthesize any DNA sequence, no matter how challenging, including those with high or low GC content, hairpin structures, or lengthy and complex sequences. They offer 100% accuracy guaranteed, which makes them a go-to company for researchers in need of DNA synthesis.
But why is gene synthesis so important to synthetic biology?
In recent years, analyzing entire genomes or collections of genes has become increasingly crucial. Gene synthesis has become a necessity due to the need for looking at mutations in the context of an organism’s genome. It can be used to study the genetic causes of various target phenotypes. Synthesizing large amounts of DNA with near-perfect fidelity has become crucial for many experiments in the field.
One fascinating avenue of research that gene synthesis has opened up is synthetic DNA vaccines. Scientists can now utilize synthetic genes to develop vaccines for different diseases. Through gene synthesis, they can create DNA sequences that code for a specific antigen. When this DNA is injected into an individual, it can produce the antigen, which triggers an immune response. This approach offers an exciting new possibility for the treatment of various diseases.
Artificial gene synthesis is undoubtedly revolutionizing synthetic biology. It is opening up endless possibilities and is quickly becoming an indispensable technique for scientists working in the field. With breakthroughs in length limitations, customization possibilities, and accuracy guarantees, the future of gene synthesis only looks brighter.
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