Synthetic DNA Libraries

Synbio Technologies offers high quality DNA libraries of any size and complexity with an efficient time frame and at industry’s most competitive rate. Our synthetic DNA libraries are designed by an experienced bioinformatics team to facilitate various research applications, including functional genetics, directed evolution, protein engineering and antibody studies.

Why us?


Proprietary synthesis platforms guarantee the successful synthesis of multiple libraries.


High quality libraries can be accurately synthesized with large capacity (up to 1014 variants), coverage rate>95%, uniformity index<10.


Flexible deliverables: oligo pools, PCR fragments, pooled plasmids, plasmid arrays, etc.

Service Specifications

Length (nt/bp)Complexity AnalysisDiversity Analysis by SequencingDelivery Time
(Business Days)
Site-Saturation Mutagenesis Library, eg.NNK Library20-40Quote10 μg linear random PCR product library (up to 1011 randomly mutated molecules) or 50-1000 ug plasmid.
Combinatorial Mutagenesis Library, eg.Trimer Library20-40Quote
Modular Substitution Library20-40Quote

Library Types

Library TypeDescriptionSchema
Alanine Scan LibraryResearch on amino acid residues critical to protein function, interaction, and shape by replacing an individual amino acid with alanine at every position.
Site-Saturation Mutagenesis LibraryMutate only one site at a time within a sequence, it can be substituted to all 20 possible amino acids or specified codons.
Combinatorial Mutagenesis LibraryMutate multiple sites within a sequence, it can be defined by customer desired amino acid types and ratios at each site.
Antibody LibraryCreate a high diversity synthetic antibody library or improve existing antibody functionality such as specificity, immunogenicity, affinity, expression, and/or aggregation.antibody-library
Modular Substitution LibraryBuild new genetic modules, regions or pathways from DNA parts including regulatory elements and/or coding sequences.
CRISPR LibraryCustomized CRISPR library and human genome CRISPR knockout library meet the screening needs of different customers.

Related Services

Next Generation Gene Synthesis

High throughput and most cost-effective.
DNA synthesis platform, starts at $0.09/bp for synthesis.

Vector Construction

shRNA, TALEN, CRISPR-Cas9 vector construction and validation.

DNA Sequencing & Gene Analysis

High quality standard present reliable gene sequencing and analysis services.

Protein Expression & Purification

Guaranteed 3 mg protein of 85% purity with our Syno® Gene to Protein Package in E. coli expression system.