Custom DNA Oligos

Synbio Technologies’s DNA oligo synthesis platform equips state-of-the-art synthesizers and leading professional teams with vast experience in oligo synthesis. This allows us to provide high-quality custom DNA oligo products to scientific researchers and industrial customers around the world. By leveraging our advanced and innovative manufacturing process, Synbio Technologies offers a wide range of custom DNA oligo synthesis options. These custom DNA oligo synthesis options include standard oligos, micro-oligos, large-scale oligos, degenerate primers, long oligos synthesis, etc.
Synbio Technologies is always competent to provide tailor-made approaches to accomplish every oligo synthesis request. Our products, certified with ISO 9001 & ISO 13485, are widely used in precision medicine, genetic disease detection, infectious disease detection, food & agriculture industries, etc.

Competitive Advantages

  • High-Quality: ISO 9001 & ISO 13485 quality certifications, extremely low mutation and low error rates, in accordance with the stringent quality control standards for oligo synthesis.
  • Good Stability: Unrivaled control of oligo specifications ensures batch-to-batch consistency and traceability.
  • Highly-Customizable: Flexible synthesis scales are available; four alternative purification options include DSL, PAGE Plus, PAGE, and HPLC.
  • Technical Support: Professional teams experienced in oligo synthesis and various modifications offer support throughout the entire production progress.
  • Cost-Effective: Competitive prices and affordable services.

Service Specifications

Synbio Technologies provides a fast and convenient standard DNA oligo synthesis. Large scale and bulk custom DNA oligos can be ordered with the same high purity, competitive prices, and fast turnaround.

Standard Oligo Synthesis (Price per Base)
Synthesis Scale10nm25nm50 nmol100 nmol200 nmol1 µmol
11-59nt$0.07$0.10$0.15$0.30$0.40$1.00
60-90nt$0.08$0.12$0.18$0.35$0.50$1.20

* Longer oligos, 96/384 plate batch oligos or other large scale synthesis are available, please contact us for a quote.
* Please refer to the purification table for the final output corresponding to different synthesis scale.

Purification (Price per Oligo)
11-59ntPurification MethodSynthesis Scale10nm25nm50 nmol100 nmol200 nmol1 µmol
DSLFinal Yield1 OD2 OD5 OD10 OD15 OD50 OD
PriceFreeFreeFreeFreeFreeFree
PAGE PlusFinal Yield2 OD5 OD10 OD30 OD
Price$5.00$5.00$5.00$5.00
PAGEFinal Yield2 OD5 OD10 OD
Price$15.00$15.00$30.00
HPLCFinal Yield2 OD5 OD10 OD
Price$10.00$10.00$20.00
60-90ntDSLFinal Yield1 OD2 OD5 OD10 OD15 OD50 OD
PriceFreeFreeFreeFreeFreeFree
PAGE PlusFinal Yield2 OD5 OD10 OD30 OD
Price$5.00$5.00$5.00$5.00
PAGEFinal Yield2 OD5 OD10 OD
Price$15.00$15.00$30.00
HPLCFinal Yield2 OD5 OD10 OD
Price$10.00$10.00$20.00

* The total price of oligo=price/base*nt + purification price.
* If you need other synthesis scale and lengths, please contact us for a quote.
* For modified oligos please click Oligo Modification & Labeling

With a micro-synthesis technology platform, Synbio Technologies can provide customers with economized micro-scale oligo synthesis services to help customers avoid the waste of experimental raw materials and reduce unnecessary costs.

Competitive Advantages
  • Cost-Effective: As low as half of the price of conventional synthesis, greatly reducing the cost of scientific research.
  • Quality Assurance: Strict quantitative analysis ensures that each oligo is mixed and delivered according to the requirements.
  • Highly-Customizable: Customized synthesis is available, including phosphoric acid, amino, biotin, and other modifications.

Service Specifications

Service TypesService Specifications
Length15-90nt, no fewer than 96 oligos
Final Yield0.1-1 nmol
PurificationDesalt or PAGE Plus
Turnaround Time/PriceInquire
DeliverablesPlate delivery or pool delivery

Synbio Technologies has large-scale synthesis and purification facilities that utilize mature and stable industrial synthesis technologies to provide high-quality, large-scale customized oligo synthesis services for global industrial production. We can provide mass production of oligos with high purity from milligram to gram quantities. These oligos are mainly used in kit development, drug discovery (ASOs drugs), aptamers, DEL (DNA encoded compound library), IVD research fields, etc.

Competitive Advantages
  • High-Quality: ISO 9001 & ISO 13485 quality certifications, strict production process and QC quality inspection.
  • Output Capacity: Diversified purification methods and strict detection standards ensure high quality output of large-scale oligos.
  • Highly Customized: Flexible synthesis scales and various modifications.

Service Specifications

Large-Scale Oligo Synthesis(Unmodified DNA Price)
Final Yield10–25 nt26–40 nt41–55 nt>55 nt
25 mg$1,338$1,451$1,761Inquire
50 mg$1,427$1,524$1,797
100 mg$1,587$1,761$2,119
200 mg$1,693$1,949$3,208
250 mg$1,787$2,042$2,480
500 mg$2,383$2,795$3,438
1 g$4,289$4,714$5,642

*If you need to know the turnaround time and the price of modified DNA oligos, please contact us for a quote.

PurificationQC AnalysisDeliverablesModifications and Probes
Backbone ModificationsLinker ModificationsqPCR Probes
HPLC/ PAGE
  • HPLC/LC-MS
  • Endotoxin Control/Bioburden (optional)
  • Lyophilized products
  • COA file
  • Phosphorothioate
  • 2’F-RNA
  • 2′-O-Methyl
  • MOE-RNA
  • LNA
  • Amino
  • Biotin
  • Thiol
  • Digoxigenin
  • Acrydite
  • DBCO
  • Azide
  • MGB Probe
  • BHQ Probe
  • Dabcyl Probe
  • TAMRA Probe

Genetic codes have the tendency to degenerate, which lead to the use of degenerate primers in PCR experiments to exhibit specific genes. Synbio Technologies provides both the design and synthesis of these degenerate primers, as well as custom degenerate oligo pool synthesis upon request.

  • Standard Service: No design fee, suitable for more than 95% PCR projects.
  • Superior Service: Utilized for certain projects sensitive to codon bias. Synbio Technologies can significantly reduce the deviation inherent in the synthesis procedures and realize the accurate proportional control.

SymbolBase TypeStandard RatioPrice
Standard LevelSuperior Level
RA,G50% : 50%FreeInquire
YC,T50% : 50%
MA,C50% : 50%
KG,T50% : 50%
SC,G50% : 50%
WA,T50% : 50%
HA,C,T33% : 33% : 33%
BC,G,T33% : 33% : 33%
VA,C,G33% : 33% : 33%
DA,G,T33% : 33% : 33%
NA,C,G,T25% : 25% : 25% : 25%

* Non-standard base proportion should be declared clearly, for example, N(20%A:30%C:40%G:10%T).

Based on the solid-phase oligo chemical synthesis technology, as the length of the synthetic sequence increasing, the undesired bands of N-1 type impurities are more unavoidable in the electrophoresis. However, some experiments still need to use long chain genes or ultra-long oligos (130-150 mer). In doing so, the synthesis efficiency and purification are pretty crucial.

Synbio Technologies’ Oligo Synthesis Platform utilizes an optimized ultra-long chain design and synthesis program to meticulously monitor and control the synthesis process. This process allows us to generate long high-quality oligos (90-129 mer) and even ultra-long oligos (130-150 mer) according to individual requests.

Length
QuantityPurification
Turnaround Time
Price
90-109 mer
1 ODPAGE / Dual-PAGE
5-6 business days
Inquire
110-129 mer
1 OD
5-7 business days
130-150 mer
0.5 OD
5-8 business days

Standard deliverables

  • Lyophilized dry DNA oligo powder, 1 tube (Transparent or dark) or 96-well and 384-well plates.
  • Certificate of Analysis (COA): including sequencing information, OD, Tm, etc.